abstract：:Animal venoms are small natural mixtures highly enriched in bioactive components. They are known to target at least two important pharmacological classes of cell surface receptors: ion channels and G protein coupled receptors. Since sperm cells express a wide variety of ion channels and membrane receptors, required fo...

journal_title：International journal of molecular sciences

authors： Abd El-Aziz TM,Jaquillard L,Bourgoin-Voillard S,Martinez G,Triquigneaux M,Zoukimian C,Combemale S,Hograindleur JP,Al Khoury S,Escoffier J,Michelland S,Bulet P,Beroud R,Seve M,Arnoult C,De Waard M

更新日期：2020-10-21 00:00:00

abstract：:ADAM9 (A disintegrin and a metalloprotease 9) is a membrane-anchored protein that participates in a variety of physiological functions, primarily through the disintegrin domain for adhesion and the metalloprotease domain for ectodomain shedding of a wide variety of cell surface proteins. ADAM9 influences the developme...

journal_title：International journal of molecular sciences

authors： Chou CW,Huang YK,Kuo TT,Liu JP,Sher YP

更新日期：2020-10-21 00:00:00

abstract：:The Duchenne muscular dystrophy (DMD) gene has a complex expression pattern regulated by multiple tissue-specific promoters and by alternative splicing (AS) of the resulting transcripts. Here, we used an RNAi-based approach coupled with DMD-targeted RNA-seq to identify RNA-binding proteins (RBPs) that regulate splicin...

journal_title：International journal of molecular sciences

authors： Miro J,Bougé AL,Murauer E,Beyne E,Da Cunha D,Claustres M,Koenig M,Tuffery-Giraud S

更新日期：2020-10-21 00:00:00

abstract：:Cannabidiol (CBD) is a biologically active, non-psychotropic component of Cannabis sativa whose popularity has grown exponentially in recent years. Besides a wealth of potential health benefits, ingestion of CBD poses risks for a number of side effects, of which hepatotoxicity and CBD/herb-drug interactions are of par...

journal_title：International journal of molecular sciences

authors： Kutanzi KR,Ewing LE,Skinner CM,Quick CM,Kennon-McGill S,McGill MR,Walker LA,ElSohly MA,Gurley BJ,Koturbash I

更新日期：2020-10-21 00:00:00

abstract：:To uncover mechanisms and explore novel biomarkers of obesity, type 2 diabetes (T2DM) and nonalcoholic steatohepatitis (NASH)-associated hepatocarcinogenesis, cellular and molecular alterations in the liver, and hepatocellular carcinomas (HCCs) were investigated in NASH model 60-week-old Tsumura, Suzuki, Obese Diabeti...

journal_title：International journal of molecular sciences

authors： Kakehashi A,Suzuki S,Ishii N,Okuno T,Kuwae Y,Fujioka M,Gi M,Stefanov V,Wanibuchi H

更新日期：2020-10-20 00:00:00

abstract：:Acute liver failure (ALF) leads to neurological symptoms defined as hepatic encephalopathy (HE). Although accumulation of ammonia and neuroinflammation are generally accepted as main contributors to HE pathomechanism, a buildup of bile acids (BA) in the blood is a frequent component of liver injury in HE patients. Rec...

journal_title：International journal of molecular sciences

authors： Czarnecka AM,Milewski K,Albrecht J,Zielińska M

更新日期：2020-10-20 00:00:00

abstract：:Prion diseases are rare transmissible neurodegenerative disorders caused by the accumulation of a misfolded isoform (PrPSc) of the cellular prion protein (PrPC) in the central nervous system (CNS). Neuropathological hallmarks of prion diseases are neuronal loss, astrogliosis, and enhanced microglial proliferation and ...

journal_title：International journal of molecular sciences

authors： Peggion C,Stella R,Lorenzon P,Spisni E,Bertoli A,Massimino ML

更新日期：2020-10-20 00:00:00

abstract：:(1) Background: Regular exercise induces physiological and morphological changes in the organisms, but excessive training loads may induce damage and impair recovery or muscle growth. The purpose of the study was to evaluate the impact of Silymarin (SM) consumption on endurance capacity, muscle/cardiac histological ch...

journal_title：International journal of molecular sciences

authors： Vargas-Mendoza N,Ángeles-Valencia M,Madrigal-Santillán EO,Morales-Martínez M,Tirado-Lule JM,Solano-Urrusquieta A,Madrigal-Bujaidar E,Álvarez-González I,Fregoso-Aguilar T,Morales-González Á,Morales-González JA

更新日期：2020-10-19 00:00:00

abstract：:The astA gene encoding an alternative sulfate transporter was originally cloned from the genome of the Japanese Aspergillus nidulans isolate as a suppressor of sulfate permease-deficient strains. Expression of the astA gene is under the control of the sulfur metabolite repression system. The encoded protein transports...

journal_title：International journal of molecular sciences

authors： Piłsyk S,Mieczkowski A,Golan MP,Wawrzyniak A,Kruszewska JS

更新日期：2020-10-19 00:00:00

abstract：:Perinatal stem cells have been regarded as an attractive and available cell source for medical research and clinical trials in recent years. Multiple stem cell types have been identified in the human placenta. Recent advances in knowledge on placental stem cells have revealed that human amniotic epithelial stem cells ...

journal_title：International journal of molecular sciences

authors： Qiu C,Ge Z,Cui W,Yu L,Li J

更新日期：2020-10-19 00:00:00

abstract：:Soil salinization, which is primarily due to excessive Na+ levels, is a major abiotic stress adversely affecting plant growth and development. The Na+/H+ antiporter (NHX) is a transmembrane protein mediating the transport of Na+ or K+ and H+ across the membrane to modulate the ionic balance of plants in response to sa...

journal_title：International journal of molecular sciences

authors： Ma W,Ren Z,Zhou Y,Zhao J,Zhang F,Feng J,Liu W,Ma X

更新日期：2020-10-18 00:00:00

abstract：:Detergent-resistant membranes (DRMs) microdomains, or "raft lipids", are key components of the plasma membrane (PM), being involved in membrane trafficking, signal transduction, cell wall metabolism or endocytosis. Proteins imbibed in these domains play important roles in these cellular functions, but there are few st...

journal_title：International journal of molecular sciences

authors： Yepes-Molina L,Carvajal M,Martínez-Ballesta MC

更新日期：2020-10-17 00:00:00

abstract：:Given the ability of molecular chaperones and chaperone-like proteins to inhibit the formation of pathological amyloid fibrils, the chaperone-based therapy of amyloidosis has recently been proposed. However, since these diseases are often diagnosed at the stages when a large amount of amyloids is already accumulated i...

journal_title：International journal of molecular sciences

authors： Stepanenko OV,Sulatsky MI,Mikhailova EV,Stepanenko OV,Povarova OI,Kuznetsova IM,Turoverov KK,Sulatskaya AI

更新日期：2020-10-16 00:00:00

abstract：:Understanding the kinetics of peptide self-assembly is important because of the involvement of peptide amyloid fibrils in several neurodegenerative diseases. In this paper, we have studied the dissolution kinetics of self-assembled model peptide fibrils after a dilution quench. Due to the low concentrations involved, ...

journal_title：International journal of molecular sciences

authors： Koder Hamid M,Rüter A,Kuczera S,Olsson U

更新日期：2020-10-16 00:00:00

abstract：:Senescence is the final stage of leaf development which is accompanied by highly coordinated and complicated reprogramming of gene expression. Genetic manipulation of leaf senescence in major crops including wheat has been shown to be able to increase stress tolerance and grain yield. NAC(No apical meristem (NAM), ATA...

journal_title：International journal of molecular sciences

authors： Zhang Z,Liu C,Guo Y

更新日期：2020-10-16 00:00:00

abstract：:Spreading of the multidrug-resistant (MDR) strains of the one of the most harmful pathogen Mycobacterium tuberculosis (Mtb) generates the need for new effective drugs. SQ109 showed activity against resistant Mtb and already advanced to Phase II/III clinical trials. Fast SQ109 degradation is attributed to the human liv...

journal_title：International journal of molecular sciences

authors： Bukhdruker S,Varaksa T,Grabovec I,Marin E,Shabunya P,Kadukova M,Grudinin S,Kavaleuski A,Gusach A,Gilep A,Borshchevskiy V,Strushkevich N

更新日期：2020-10-16 00:00:00

abstract：:Genetically modified vaccinia viruses (VACVs) have been shown to possess profound oncolytic capabilities. However, tumor cell resistance to VACVs may endanger broad clinical success. Using cell mass assays, viral replication studies, and fluorescence microscopy, we investigated primary resistance phenomena of cell lin...

journal_title：International journal of molecular sciences

authors： Berchtold S,Beil J,Raff C,Smirnow I,Schell M,D'Alvise J,Gross S,Lauer UM

更新日期：2020-10-15 00:00:00

abstract：:Previously, we demonstrated that the immediate administration of multitarget anxiolytic afobazole slows down the progression of neuronal damage in a 6-hydroxidodamine (6-OHDA) model of Parkinson's disease due to the activation of chaperone Sigma1R. The aim of the present study is to evaluate the therapeutic potential ...

journal_title：International journal of molecular sciences

authors： Kadnikov IA,Verbovaya ER,Voronkov DN,Voronin MV,Seredenin SB

更新日期：2020-10-15 00:00:00

abstract：:As most chemotherapeutic drugs are ineffective in the treatment of chondrosarcoma, we studied the expression pattern and function of SOX9, the master transcription factor for chondrogenesis, in chondrosarcoma, to understand the basic molecular principles needed for engineering new targeted therapies. Our study shows a...

journal_title：International journal of molecular sciences

authors： Stöckl S,Lindner G,Li S,Schuster P,Haferkamp S,Wagner F,Prodinger PM,Multhoff G,Boxberg M,Hillmann A,Bauer RJ,Grässel S

更新日期：2020-10-15 00:00:00

abstract：:The growth arrest-specific transcript 5 (GAS5) is a >200-nt lncRNA molecule that regulates several cellular functions, including proliferation, apoptosis, invasion and metastasis, across different types of human cancers. Here, we reviewed the current literature on the expression of GAS5 in leukemia, cervical, breast, ...

journal_title：International journal of molecular sciences

authors： Lambrou GI,Hatziagapiou K,Zaravinos A

更新日期：2020-10-15 00:00:00

abstract：:Arterial calcification, the deposition of calcium-phosphate crystals in the extracellular matrix, resembles physiological bone mineralization. It is well-known that extracellular nucleotides regulate bone homeostasis raising an emerging interest in the role of these molecules on arterial calcification. The purinergic ...

journal_title：International journal of molecular sciences

authors： Opdebeeck B,Orriss IR,Neven E,D'Haese PC,Verhulst A

更新日期：2020-10-15 00:00:00

abstract：:Research on the protein folding problem differentiates the protein folding process with respect to the duration of this process. The current structure encoded in sequence dogma seems to be clearly justified, especially in the case of proteins referred to as fast-folding, ultra-fast-folding or downhill. In the present ...

journal_title：International journal of molecular sciences

authors： Banach M,Stapor K,Konieczny L,Fabian P,Roterman I

更新日期：2020-10-15 00:00:00

abstract：:Placental homeostasis of tryptophan is essential for fetal development and programming. The two main metabolic pathways (serotonin and kynurenine) produce bioactive metabolites with immunosuppressive, neurotoxic, or neuroprotective properties and their concentrations in the fetoplacental unit must be tightly regulated...

journal_title：International journal of molecular sciences

authors： Abad C,Karahoda R,Kastner P,Portillo R,Horackova H,Kucera R,Nachtigal P,Staud F

更新日期：2020-10-14 00:00:00

abstract：:Previous studies have demonstrated that microgravity could lead to health risks. The investigation of the molecular mechanisms from the aspect of systems biology has not been performed yet. Here, we integratively analyzed transcriptional and post-transcriptional regulations based on gene and miRNA expression profiles ...

journal_title：International journal of molecular sciences

authors： Yuan M,Liu H,Zhou S,Zhou X,Huang YE,Hou F,Jiang W

更新日期：2020-10-14 00:00:00

abstract：:Awns, which are either bristles or hair-like outgrowths of lemmas in the florets, are one of the typical morphological characteristics of grass species. These stiff structures contribute to grain dispersal and burial and fend off animal predators. However, their phenotypic and genetic associations with traits deciding...

journal_title：International journal of molecular sciences

authors： Ntakirutimana F,Xie W

更新日期：2020-10-14 00:00:00

abstract：:RNA isolated from fixed and paraffin-embedded tissues is widely used in biomedical research and molecular pathology for diagnosis. In the present study, we have set-up a method based on high performance liquid chromatography (HPLC) to investigate the effects of different fixatives on RNA. By the application of the pre...

journal_title：International journal of molecular sciences

authors： Fattorini P,Forzato C,Tierno D,De Martino E,Azzalini E,Canzonieri V,Stanta G,Bonin S

更新日期：2020-10-13 00:00:00

abstract：:Poly(l-lactide-co-glycolide) (PLGA) porous scaffolds were modified with collagen type I (PLGA/coll) or hydroxyapatite (PLGA/HAp) and implanted in rabbits osteochondral defects to check their biocompatibility and bone tissue regeneration potential. The scaffolds were fabricated using solvent casting/particulate leachin...

journal_title：International journal of molecular sciences

authors： Krok-Borkowicz M,Reczyńska K,Rumian Ł,Menaszek E,Orzelski M,Malisz P,Silmanowicz P,Dobrzyński P,Pamuła E

更新日期：2020-10-13 00:00:00

abstract：:Nitrogen (N) is an essential nutrient for plant growth and development. Plant species respond to N fluctuations and N sources, i.e., ammonium or nitrate, differently. Masson pine (Pinus massoniana Lamb.) is one of the pioneer plants in the southern forests of China. It shows better growth when grown in medium containi...

journal_title：International journal of molecular sciences

authors： Ren Q,Zhou Y,Zhou X

更新日期：2020-10-13 00:00:00

abstract：:Aging is a major risk factor of osteoarthritis, which is characterized by the degeneration of articular cartilage. CCN3, a member of the CCN family, is expressed in cartilage and has various physiological functions during chondrocyte development, differentiation, and regeneration. Here, we examine the role of CCN3 in ...

journal_title：International journal of molecular sciences

authors： Kuwahara M,Kadoya K,Kondo S,Fu S,Miyake Y,Ogo A,Ono M,Furumatsu T,Nakata E,Sasaki T,Minagi S,Takigawa M,Kubota S,Hattori T

更新日期：2020-10-13 00:00:00

abstract：:The success of antibody therapeutics is strongly influenced by their multifunctional nature that couples antigen recognition mediated by their variable regions with effector functions and half-life extension mediated by a subset of their constant regions. Nevertheless, the monospecific IgG format is not optimal for ma...

journal_title：International journal of molecular sciences

authors： Sawant MS,Streu CN,Wu L,Tessier PM

更新日期：2020-10-12 00:00:00

abstract：:Platelets (PLT) are the second most abundant cell type in human blood and exert various immune-regulatory functions under both physiological and pathological conditions. In fact, immune cell regulation via platelets has been demonstrated in several studies within the past decade. However, the exact mechanisms behind T...

journal_title：International journal of molecular sciences

authors： Polasky C,Wendt F,Pries R,Wollenberg B

更新日期：2020-10-12 00:00:00

abstract：:The enzyme Cypridina luciferase (CLase) enables Cypridina luciferin to emit light efficiently through an oxidation reaction. The catalytic mechanism on the substrate of CLase has been studied, but the details remain to be clarified. Here, we examined the luminescence of Cypridina luciferin in the presence of several p...

journal_title：International journal of molecular sciences

authors： Kanie S,Komatsu M,Mitani Y

更新日期：2020-10-12 00:00:00

abstract：:Most pharmaceutical substances interact with several or even many molecular targets in the organism, determining the complex profiles of their biological activity. Moreover, due to biotransformation in the human body, they form one or several metabolites with different biological activity profiles. Therefore, the deve...

journal_title：International journal of molecular sciences

authors： Filimonov DA,Rudik AV,Dmitriev AV,Poroikov VV

更新日期：2020-10-11 00:00:00

abstract：:The paper presents the synthesis of an enaminone resorcin[4]arene via a thermally activated o-quinomethide. The crystal structure indicates that in the solid state all enaminone units participate in a unidirectional seam of 12 intramolecular hydrogen bonds that are formed around the cavity. The molecule exhibits C2 sy...

journal_title：International journal of molecular sciences

authors： Szafraniec A,Grajda M,Jędrzejewska H,Szumna A,Iwanek W

更新日期：2020-10-11 00:00:00

abstract：:In this study, we optimized the geometry and composition of additive-manufactured pedicle screws. Metal powders of titanium-aluminum-vanadium (Ti-6Al-4V) were mixed with reactive glass-ceramic biomaterials of bioactive glass (BG) powders. To optimize the geometry of pedicle screws, we applied a novel numerical approac...

journal_title：International journal of molecular sciences

authors： Lam TN,Trinh MG,Huang CC,Kung PC,Huang WC,Chang W,Amalia L,Chin HH,Tsou NT,Shih SJ,Chen SY,Wang CC,Tsai PI,Wu MH,Huang EW

更新日期：2020-10-09 00:00:00

abstract：:Emotional and cognitive information processing represent higher-order brain functions. They require coordinated interaction of specialized brain areas via a complex spatial and temporal equilibrium among neuronal cell-autonomous, circuitry, and network mechanisms. The delicate balance can be corrupted by stressful exp...

journal_title：International journal of molecular sciences

authors： Italia M,Forastieri C,Longaretti A,Battaglioli E,Rusconi F

更新日期：2020-10-09 00:00:00

abstract：OBJECTIVES:Bladder cancer is a heterogeneous malignancy. Therefore, it is difficult to find single predictive markers. Moreover, most studies focus on either the immunohistochemical or molecular assessment of tumor tissues by next-generation sequencing (NGS) or PCR, while a combination of immunohistochemistry (IHC) and...

journal_title：International journal of molecular sciences

authors： Ecke TH,Kiani A,Schlomm T,Friedersdorff F,Rabien A,Jung K,Kilic E,Boström P,Tervahartiala M,Taimen P,Gleichenhagen J,Johnen G,Brüning T,Koch S,Roggisch J,Wirtz RM

更新日期：2020-10-08 00:00:00

abstract：:VDACs (voltage-dependent anion-selective channels) are pore-forming proteins of the outer mitochondrial membrane, whose permeability is primarily due to VDACs' presence. In higher eukaryotes, three isoforms are raised during the evolution: they have the same exon-intron organization, and the proteins show the same cha...

journal_title：International journal of molecular sciences

authors： Zinghirino F,Pappalardo XG,Messina A,Guarino F,De Pinto V

更新日期：2020-10-07 00:00:00

abstract：:CX3CL1 can function as both an adhesion molecule and a chemokine for CX3CR1+ cells, such as T cells, monocytes, and NK cells. Recent studies have demonstrated that CX3CL1-CX3CR1 interaction is associated with the development of various inflammatory skin diseases. In this study, we examined CX3CR1 involvement in 2,4-di...

journal_title：International journal of molecular sciences

authors： Otobe S,Hisamoto T,Miyagaki T,Morimura S,Suga H,Sugaya M,Sato S

更新日期：2020-10-07 00:00:00

abstract：:Bacterial biofilm formation on wet surfaces represents a significant problem in medicine and environmental sciences. One of the strategies to prevent or eliminate surface adhesion of organisms is surface modification and coating. However, the current coating technologies possess several drawbacks, including limited du...

journal_title：International journal of molecular sciences

authors： Ya'ari S,Halperin-Sternfeld M,Rosin B,Adler-Abramovich L

更新日期：2020-10-06 00:00:00